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The full arc is in the pillar update

Investigating Liver Detoxification and Methylation A targeted history and laboratory assessment may help distinguish excessive exposure from impaired methylation, elevated SAH, poor transsulfuration, low glutathione, biliary dysfunction or gut-derived toxic burden

In: Erdman Jr J, Macdonald J, Zeisel S, eds

15 Phase II trials targeting MASH have shown that treatment with SEMA 0.4 mg daily for 72 weeks resulted in more patients with liver fibrosis stage F2/F3 achieving improvement in MASH without progression of liver fibrosis (odds ratio = 6.87, 95% CI = 2.6017.63) compared to placebo